May 19, 2018

Hyaluronidase Aftercare

Written by Dr Kate Jameson

Dr Kate

Thank you for attending Youth Lab for Hyaluronidase treatment. Please take the time to carefully read the post-treatment instructions below.


  • Apply a cool compress to the treatment area.
  • Avoid any heat-inducing activities for 24 hours.
  • Do not perform strenuous exercise for 24 hours. 
  • Avoid pressure on the area for the first 48 hours (i.e. avoid face down massages).
  • Do not massage the treatment area unless instructed to do so.
  • Avoid alcohol for 24 hours.
  • Avoid active cosmeceutical products (AHAs, retinol, vitamin C) for 24 hours.
  • Do not apply oil based makeup for 24 hours. 
  • Avoid blood thinning medication such as Aspirin & Ibuprofen for 7 days (unless medically necessary)
  • Avoid facial treatments for 2 weeks after treatment (including facials, waxing, chemical peels, skin needling, Hydrafacial, IPL or laser)
  • Do not smoke, vape or drink from a straw for 4 days post treatment. 
  • Use a topical treatment to soothe the skin such as Bepanthen or Arnica cream.


The listed below are all normal side effects and should self resolve within a few days. 

  • Redness
  • Swelling
  • Pain
  • Itching
  • Bruising (Bruising may occasionally be more significant than with dermal filler injections). 
  • Tenderness

For further information on how to manage these side effects, please see ‘Management’. 

More severe complications may include:

Hyalase administration can result in anaphylaxis (a severe allergic reaction) which in itself is life threatening and requires immediate medical attention. 

Symptoms of a severe allergic reaction can include 

  • Shortness of breath.
  • Wheezing.
  • Coughing.
  • Difficulty swallowing.
  • Swelling of the tongue, eyelids or lips.
  • Hoarseness of the voice.
  • Stomach pain, nausea or diarrhoea.

If you have any of the above severe symptoms, please report to your nearest Emergency Department or call 000 for an ambulance.



Swelling is a normal response to Hyalase. Swelling may appear asymmetrical, but this is normal and not an indication of the end result. The swelling should subside within a couple of days. 

Swelling Relief

  • Apply a cool compress to the area  for 10 minutes every hour on treatment day.
  • Take an antihistamine (e.g. 10mg loratadine)
  • Try sleeping on your back, slightly elevated, to prevent pressure build-up on the face 


Bruising is a common and expected side effect. This is not due to poor technique and will not alter the final result of your treatment. In order to reduce bruising, it is important to adhere to the aftercare regime. 

Bruising Relief

  • Avoid any medications containing NSAIDs, aspirin, vitamin E and ginseng for the week prior and the week following treatment, unless medically necessary and after discussion with your doctor/nurse.
  • Apply a cool compress to the area for 10 minutes every hour on treatment day.
  • Apply topical Arnica or Hirudoid cream to the affected area. 

We offer HEALITE II LED treatments for those cases where bruising is severe and not manageable with home remedies. 


How long until I will see results?

Although some of the effects can be immediate, it can take up to 2 weeks for the final results to be seen and the procedure may need to be repeated.

Further dissolving with Hyalase may need to be performed, this is best done 14 days after the initial treatment.

How long after the Hyaluronidase can I get Dermal Filler? 

Further treatment with dermal filler to the corrected area can be performed no sooner than 14 days after the last treatment with Hyalase. 

Will the Hyaluronidase cause skin laxity? 

Hyalase is an enzyme that breaks down hyaluronic acid fillers, but it can also break down naturally occurring hyaluronic acid present in the body. The results can be unpredictable and the effect dramatic with possible loss of volume and some skin laxity.

Please contact the clinic on (08) 9324 1604 (West Perth), (08) 9260 6800 (Claremont) or at (08) 9260 6880 (Joondalup) if you have any questions about your treatment or aftercare instructions.