April 15, 2024

Rejuran Aftercare

Written by Dr Kate Jameson


Thank you for attending Youth Lab for Polynucleotide / Rejuran  Injections. Please take the time to carefully read your post-treatment instructions below.


  • Avoid any heat-inducing activities for 24 hours.
  • Do not perform strenuous exercise for 24 hours. 
  • Avoid pressure on the area for 48 hours (i.e. avoid face-down massages).
  • Do not massage the treatment area unless instructed to do so.
  • Avoid alcohol for 24 hours.
  • Avoid active cosmeceutical products (AHAs, retinol, vitamin C) for 24 hours.
  • Do not apply oil-based makeup for 24 hours. 
  • Avoid blood thinning medication such as Aspirin & Ibuprofen for 7 days (unless medically necessary)


The listed below are all normal side effects and should self resolve within a few days. 

  • Swelling/lumps (Expected time prior to bumps subsiding can be 3-5 days)
  • Bruising 
  • Redness 
  • Tenderness  

For further information on how to manage these side effects, please see ‘Management’. 

More severe complications may include:

  • Pain out of proportion to the expected post treatment discomfort
  • Severe swelling
  • Possible allergic reaction
  • Blanching or whitening of the skin
  • Visual disturbances or any change to mental state

If you experience any of the above severe complications please contact the clinic on (08) 9324 1604 (West Perth), (08) 9260 6800 (Claremont), (08) 9260 6880 (Joondalup), or at (08) 9260 6820 (Applecross) 



Swelling after the Rejuran treatment is expected. The swelling is often localised and resembles small lumps. As the product spreads the swelling (or ‘lumps’) will dissipate. 

The swelling will resolve within 3-5 days and does not require any intervention. If the swelling persists for more than 5 days please inform the clinic. 

Swelling Relief

  • You can apply a cool compress for 10 minutes every hour on treatment day. 


Bruising is a common and expected side effect. Bruising is not due to poor technique and will not alter the final result of your treatment. In order to reduce bruising, it is important to adhere to the aftercare regime. 

Bruising Relief

  • Avoid any medications containing NSAIDs, aspirin, vitamin E and ginseng for the week prior and the week following treatment, unless medically necessary and after discussion with your doctor/nurse.
  • Apply a cool compress to the area for 10 minutes every hour on treatment day.
  • Apply topical Arnica or Hirudoid cream to the affected area. 

We offer HEALITE II LED treatments for those cases where bruising is severe and not manageable with home remedies. 

Rarer side effects are discussed with each patient in the consultation process and are not expected with every treatment.


How many treatments do I need?

An initial treatment course of 3-4 treatments, spaced 4 weeks apart, is required. Many may need a fourth session depending on their skin quality. Once this is complete, to ensure longevity, it is recommended to have a maintenance treatment every 6 months. 

Please discuss your individual treatment plan with your practitioner as results may vary. 

When will I see results? 

Results begin to show within the first week of the treatment. However, best results are seen 8-12 weeks post the completion of the treatment course. 

How long does the treatment last?

The results from Rejuran are long-lasting, but not permanent. Longevity depends on the volume of product injected, its indication, compliance with aftercare and the baseline condition of the skin. We cannot guarantee the longevity of the results. 

Regular maintenance treatments are required and essential for long-lasting results.

Please contact the clinic on (08) 9324 1604 (West Perth), (08) 9260 6800 (Claremont), (08) 9260 6880 (Joondalup), or (08) 9260 6820 (Applecross) if you have any questions about your treatment or aftercare instructions.